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Peptide record

TPDB17320

Antibacterial Antifungal Toxicity standard
55 amino acids
Basic Information
3D PDB MODEL
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TPDB17320
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 55-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
FNNLPICVEGLAGDIGSILLGVESDIGALAGAIANLALIAGECAAQGEAGAAICA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C225H371N59O74S3
RHKMTWY
A
5182.95
2.76
0
6
30
-6
-0.71
1.062
133.45
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
0.02
9
Residue Composition
number
13
A
0
R
3
N
2
D
3
C
4
E
1
Q
9
G
0
H
7
I
7
L
0
K
0
M
1
F
1
P
2
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 13 R: 0 N: 3 D: 2 C: 3 E: 4 Q: 1 G: 9 H: 0 I: 7 L: 7 K: 0 M: 0 F: 1 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
55 reviewed residue count
C225H371N59O74S3 sequence-only estimate (linear, free termini)
5182.95 sequence-only estimate (linear, free termini)
2.76 sequence-only estimate (linear, free termini)
-6 sequence-only estimate (linear, free termini)
-0.71 sequence-only estimate (linear, free termini)
1.062 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Toxicity
24.42 µM
Cytotoxic
IC50 | 24.42 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022