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Peptide record

TPDB17319

Antibacterial Antifungal Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB17319
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 45-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
RSLWKKIFKPVEKLGQRVRDAGIQGIAIAQQGANVLATVRGGPPQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C217H364N68O58
CHMY
G
4853.70
11.99
8
2
18
+6
1.49
-0.293
97.56
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
1.13
8
Residue Composition
number
5
A
4
R
1
N
1
D
0
C
1
E
5
Q
6
G
0
H
4
I
3
L
4
K
0
M
1
F
3
P
1
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 5 R: 4 N: 1 D: 1 C: 0 E: 1 Q: 5 G: 6 H: 0 I: 4 L: 3 K: 4 M: 0 F: 1 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
45 reviewed residue count
C217H364N68O58 sequence-only estimate (linear, free termini)
4853.70 sequence-only estimate (linear, free termini)
11.99 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.49 sequence-only estimate (linear, free termini)
-0.293 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
0.5-1.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
>64 µM
Cytotoxic
IC50 | >64 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022