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Peptide record

TPDB17317

Antibacterial Antifungal Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB17317
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 45-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
GWWKRVFKPVEKFGQRVRDAGIQGIEIAQQGANVLATARGGPPQQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C222H351N69O60
CHMSY
G
4946.66
11.39
7
3
17
+4
1.76
-0.580
71.56
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
2.22
8
Residue Composition
number
5
A
4
R
1
N
1
D
0
C
2
E
6
Q
7
G
0
H
3
I
1
L
3
K
0
M
2
F
3
P
0
S
1
T
2
W
0
Y
4
V
Amino Acid Distribution
A: 5 R: 4 N: 1 D: 1 C: 0 E: 2 Q: 6 G: 7 H: 0 I: 3 L: 1 K: 3 M: 0 F: 2 P: 3 S: 0 T: 1 W: 2 Y: 0 V: 4
Chemical Descriptors
45 reviewed residue count
C222H351N69O60 sequence-only estimate (linear, free termini)
4946.66 sequence-only estimate (linear, free termini)
11.39 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
1.76 sequence-only estimate (linear, free termini)
-0.580 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 4-8 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 4-8 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
1-2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 4-8 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
4-8 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 4-8 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
>64 µM
Cytotoxic
IC50 | >64 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022