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Peptide record

TPDB17316

Antibacterial Antifungal Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB17316
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 44-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
GWWKKVFKPVEKLGQRVRDAGIQGIAIAQQGANVLATVRGGPPQ
Physicochemical Analysis
C214H347N65O56
CHMSY
G
4726.51
11.53
7
2
18
+5
7.14
-0.302
88.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
232.73
7
Residue Composition
number
5
A
3
R
1
N
1
D
0
C
1
E
5
Q
7
G
0
H
3
I
2
L
4
K
0
M
1
F
3
P
0
S
1
T
2
W
0
Y
5
V
Amino Acid Distribution
A: 5 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 5 G: 7 H: 0 I: 3 L: 2 K: 4 M: 0 F: 1 P: 3 S: 0 T: 1 W: 2 Y: 0 V: 5
Chemical Descriptors
44
C214H347N65O56
4726.51
11.53
+5
7.14
-0.302
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 2-4 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 2-4 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
1-2 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 2-4 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
2-4 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 1-2 uM), P. aeruginos (MIC 2-4 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
>64 µM
Cytotoxic
IC50 | >64 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022
Evidence 6 Activity

Activity

<5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022