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Peptide record

TPDB17314

Antibacterial Antifungal Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB17314
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 44-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
SWFKKVFKPVEKVGQRVRDAGIQGVAIAQQGANVLATARGGPPH
Physicochemical Analysis
C210H339N65O56
CMY
AGV
4670.40
11.53
8
2
18
+5
9.13
-0.273
79.77
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
117.76
7
Residue Composition
number
6
A
3
R
1
N
1
D
0
C
1
E
4
Q
6
G
1
H
2
I
1
L
4
K
0
M
2
F
3
P
1
S
1
T
1
W
0
Y
6
V
Amino Acid Distribution
A: 6 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 4 G: 6 H: 1 I: 2 L: 1 K: 4 M: 0 F: 2 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 6
Chemical Descriptors
44
C210H339N65O56
4670.40
11.53
+5
9.13
-0.273
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1 uM), P. aeruginos (MIC 16-32 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
16-32 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1 uM), P. aeruginos (MIC 16-32 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
0.5-1 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1 uM), P. aeruginos (MIC 16-32 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
16-32 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1 uM), P. aeruginos (MIC 16-32 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
>64 µM
Cytotoxic
IC50 | >64 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022