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Peptide record

TPDB17307

Antibacterial Antifungal Toxicity standard
65 amino acids
Basic Information
3D PDB MODEL
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TPDB17307
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 65-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
QIFAQGGGSPGKGYDIYAQGRAKLWESQNQRNSLHGTASYSQHLGGPYGNSRPNVGGGLTFTHRF
Physicochemical Analysis
C307H458N96O93
CM
G
6981.60
10.27
9
2
19
+4
6.72
-0.868
46.62
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
11460
164.15
23
Residue Composition
number
4
A
4
R
4
N
1
D
0
C
1
E
6
Q
13
G
3
H
2
I
4
L
2
K
0
M
3
F
3
P
6
S
3
T
1
W
4
Y
1
V
Amino Acid Distribution
A: 4 R: 4 N: 4 D: 1 C: 0 E: 1 Q: 6 G: 13 H: 3 I: 2 L: 4 K: 2 M: 0 F: 3 P: 3 S: 6 T: 3 W: 1 Y: 4 V: 1
Chemical Descriptors
65
C307H458N96O93
6981.60
10.27
+4
6.72
-0.868
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 2.0 uM), P-aeruginos (MIC >32-64 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
2.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 2.0 uM), P-aeruginos (MIC >32-64 uM).
Evidence 3 Activity

Activity

IC50
Toxicity
7.73 µM
Cytotoxic
IC50 | 7.73 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022