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Peptide record

TPDB17297

Antibacterial Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB17297
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 11-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
WKKLKKLLKKL
Physicochemical Analysis
C71H128N18O12
ARNDCEQGHIMFPSTYV
K
1425.91
11.21
6
0
5
+6
1.85
-0.827
141.82
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
385.72
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
6
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
11
C71H128N18O12
1425.91
11.21
+6
1.85
-0.827
Evidence Records 6 records
Evidence 1 Activity

Activity

3.15% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
3.15% Hemolysis | 256 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii | Front Microbiol | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
68.1 µg/mL
Cytotoxic
IC50 | 68.1 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii | Front Microbiol | 2021
Evidence 3 Activity

Activity

70% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
70% Hemolysis | 256 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii | Front Microbiol | 2021
Evidence 4 Activity

Activity

86.03% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
86.03% Hemolysis | 256 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii | Front Microbiol | 2021
Evidence 5 Activity

Activity

54.07% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
54.07% Hemolysis | 256 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii | Front Microbiol | 2021
Evidence 6 Activity

Activity

7.89% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
7.89% Hemolysis | 256 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii | Front Microbiol | 2021