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Peptide record

TPDB17258

STIP3-29 Antibacterial Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB17258
STIP3-29
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
TVGGLVKWILKTVKKFA-NH2
Physicochemical Analysis
C92H154N22O20
RNDCEQHMPSY
K
1888.37
11.00
4
0
9
+4
-0.11
0.624
125.88
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
291.26
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
4
K
0
M
1
F
0
P
0
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 4 M: 0 F: 1 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
17
C92H154N22O20
1888.37
11.00
+4
-0.11
0.624
Amidation
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mrsa Atcc 33592 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
SYTOX Green fluorescenct dye and (FAM)-labeled
Cytoplasm
Rapid and concentration-dependent increases in fluorescence were observed, consistent with STIP3-29 treatment, providing the dye access to bind DNA.
In vitro and ex vivo
CCTHHHHHHHGGGHHHHHHTCC
Additional Detail Fields 1 fields
CCTHHHHHHHGGGHHHHHHTCC