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Peptide record

TPDB17249

Antibacterial Anticancer Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB17249
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia ToxinPred 3.0
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
WNWSKSF
Physicochemical Analysis
C47H59N11O11
ARDCEQGHILMPTYV
SW
954.05
10.10
1
0
3
+1
-3.16
-1.143
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
1152.98
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
2
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 2 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
7
C47H59N11O11
954.05
10.10
+1
-3.16
-1.143
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

S. Typhimurium LT2 ATCC 19585

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
), K. pneumoniae ATCC 700603 (SHV-18), K. pneumoniae ATCC BAA-1705 (KPC), E. coli MG1655, S. Typhimurium LT2 ATCC 19585 (MIC 4 ug/ml), M. catarrhalis ATCC 25238, A. baumannii ATCC 17978 (MIC 8 ug/ml), P. aeruginosa JMI 1045
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

A. baumannii ATCC 17978

Source & Reference

dbAMP

Other

, E. coli MG1655, S. Typhimurium LT2 ATCC 19585 (MIC 4 ug/ml), M. catarrhalis ATCC 25238, A. baumannii ATCC 17978 (MIC 8 ug/ml), P. aeruginosa JMI 1045324 (MIC 16 uM), E. cloacae ATCC 13047 (MIC 32 ug/ml), and P. mira
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa JMI 1045324

Source & Reference

dbAMP

Other

CC 19585 (MIC 4 ug/ml), M. catarrhalis ATCC 25238, A. baumannii ATCC 17978 (MIC 8 ug/ml), P. aeruginosa JMI 1045324 (MIC 16 uM), E. cloacae ATCC 13047 (MIC 32 ug/ml), and P. mirabilis KLE 2600 (MIC 64 ug/ml). Not acti
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Enterobacter cloacae ATCC 13047

Source & Reference

dbAMP

Other

ATCC 25238, A. baumannii ATCC 17978 (MIC 8 ug/ml), P. aeruginosa JMI 1045324 (MIC 16 uM), E. cloacae ATCC 13047 (MIC 32 ug/ml), and P. mirabilis KLE 2600 (MIC 64 ug/ml). Not active agains the Gram+ bacteria tested.
Evidence 5 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

P. mirabilis KLE 2600

Source & Reference

dbAMP

Other

ug/ml), P. aeruginosa JMI 1045324 (MIC 16 uM), E. cloacae ATCC 13047 (MIC 32 ug/ml), and P. mirabilis KLE 2600 (MIC 64 ug/ml). Not active agains the Gram+ bacteria tested.
Evidence 6 Activity

Activity

IC50
Toxicity
>128 µg/mL
Cytotoxic
IC50 | >128 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
A new antibiotic selectively kills Gram-negative pathogens. | Nature | 2019