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Peptide record

TPDB17187

Cathelicidin-MH Anti-inflammatory Antibacterial Antifungal Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB17187
Cathelicidin-MH
Anti-inflammatory Antibacterial Antifungal Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia dbAMP AFP-GFuse CAFPdb DBAASP
standard
No
A 39-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, dbAMP, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
APCKLGCKIKKVKQKIKQKLKAKVNAVKTVIGKISEHLG
Physicochemical Analysis
C192H348N56O47S2
RDMFWY
K
4257.34
10.81
13
1
14
+11
13.56
-0.300
107.44
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
2.94
7
Residue Composition
number
3
A
0
R
1
N
0
D
2
C
1
E
2
Q
3
G
1
H
4
I
3
L
12
K
0
M
0
F
1
P
1
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 2 E: 1 Q: 2 G: 3 H: 1 I: 4 L: 3 K: 12 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
39
C192H348N56O47S2
4257.34
10.81
+11
13.56
-0.300
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtil
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. al
Evidence 4 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

B. subtilis CMCC 63501

Source & Reference

dbAMP

Other

6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. albicans ATCC 10231 (MIC 12.5 uM). Also,
Evidence 5 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

P. acnes ATCC 6919

Source & Reference

dbAMP

Other

IC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. albicans ATCC 10231 (MIC 12.5 uM). Also, inhibited the enzymatic activitie
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

0 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. albicans ATCC 10231 (MIC 12.5 uM). Also, inhibited the enzymatic activities of tPA, plasmin, b-tryptase, elastase, and thro
Evidence 7 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtil
Evidence 8 Activity

Activity

MIC
Antifungal
25 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb

Other

Active against Gram- E. coli (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes
Evidence 9 Activity

Activity

MIC
Antifungal
>100 µM

Target

S.aureus ATCC 25923

Source & Reference

dbAMP CAFPdb

Other

Active against Gram- E. coli (MIC 6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. al
Evidence 10 Activity

Activity

MIC
Antifungal
6.25 µM

Target

B. subtilis CMCC 63501

Source & Reference

dbAMP CAFPdb

Other

6.25 uM), P. aeruginosa ATCC 27853 (MIC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. albicans ATCC 10231 (MIC 12.5 uM). Also,
Evidence 11 Activity

Activity

MIC
Antifungal
1.56 µM

Target

P. acnes ATCC 6919

Source & Reference

dbAMP CAFPdb

Other

IC 25 uM), Gram+ S.aureus ATCC 25923 (MIC >100 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. albicans ATCC 10231 (MIC 12.5 uM). Also, inhibited the enzymatic activitie
Evidence 12 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb

Other

0 uM), B. subtilis CMCC 63501 (MIC 6.25 uM), P. acnes ATCC 6919 (MIC 1.56 uM), and fungal C. albicans ATCC 10231 (MIC 12.5 uM). Also, inhibited the enzymatic activities of tPA, plasmin, b-tryptase, elastase, and thro
Evidence 13 Activity

Activity

2.64±1.4% Hemolysis
Toxicity
212.77 µg/mL
Hemolytic Cytotoxic
2.64±1.4% Hemolysis | 212.77 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties. | eLife | 2021
Evidence 14 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP