Back to search

Peptide record

TPDB17093

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB17093
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
KRIVQRIKDWLRKLCKKW
Physicochemical Analysis
C111H189N35O22S1
ANEGHMFPSTY
K
2398.00
11.58
8
1
7
+7
3.58
-1.028
102.78
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
458.72
2
Residue Composition
number
0
A
3
R
0
N
1
D
1
C
0
E
1
Q
0
G
0
H
2
I
2
L
5
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
18
C111H189N35O22S1
2398.00
11.58
+7
3.58
-1.028
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
54.6 µg/mL
Cytotoxic
50% Cell death | 54.6 | µg/mL | target cell: Human corneal epithelial cells HCE-2

Target

Human corneal epithelial cells HCE-2

Source & Reference

NA
DBAASP
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. | Sci Rep | 2021
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. | Sci Rep | 2021
Evidence 3 Activity

Activity

7.1% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
7.1% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. | Sci Rep | 2021
Evidence 4 Activity

Activity

69.6% Killing
Toxicity
200 µg/mL
Cytotoxic
69.6% Killing | 200 | µg/mL | target cell: Human corneal epithelial cells HCE-2

Target

Human corneal epithelial cells HCE-2

Source & Reference

NA
DBAASP
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis. | Sci Rep | 2021