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Peptide record

TPDB17067

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB17067
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FFFIRRIARLLRRIF
Physicochemical Analysis
C99H158N30O16
NDCEQGHKMPSTWYV
R
2024.54
13.00
5
0
10
+5
-2.69
0.773
136.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
0
K
0
M
4
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 0 M: 0 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C99H158N30O16
2024.54
13.00
+5
-2.69
0.773
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against multiple clinical Salmonella strains (MIC 4-8 uM). MBC values are identical, indicating bactericidal. Showed an effect on biofilms:bacteria as well. Warning: Other bacteria not tested.
Evidence 2 Activity

Activity

61.6% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
61.6% Hemolysis | 8 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella. | Molecules | 2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
5.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 5.6 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella. | Molecules | 2021