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Peptide record

TPDB17048

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB17048
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FIRRIARLLRRIF
Physicochemical Analysis
C81H140N28O14
NDCEQGHKMPSTWYV
R
1730.18
13.00
5
0
8
+5
-0.43
0.462
157.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C81H140N28O14
1730.18
13.00
+5
-0.43
0.462
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Staphylococcus aureus ATCC 29212 or MRSA

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus ATCC 29212 or MRSA (MIC 5 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 2.5 ug
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5-5.0 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

active against S. aureus ATCC 29212 or MRSA (MIC 5 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 2.5 ug/ml), and E. coli ATCC 25922 (MIC 10
Evidence 3 Activity

Activity

MIC
Antibacterial
5-10 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

e against S. aureus ATCC 29212 or MRSA (MIC 5 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 2.5 ug/ml), and E. coli ATCC 25922 (MIC 10 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
2.5 µg/mL

Target

E. faecium

Source & Reference

dbAMP

Other

or MRSA (MIC 5 ug/ml), S. epidermidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 2.5 ug/ml), and E. coli ATCC 25922 (MIC 10 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

rmidis (MIC 2.5-5.0 ug/ml), E. faecalis (MIC 5-10 ug/ml), E. faecium (MIC 2.5 ug/ml), and E. coli ATCC 25922 (MIC 10 ug/ml).
Evidence 6 Activity

Activity

73.1% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
73.1% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fine-Tuning of Alkaline Residues on the Hydrophilic Face Provides a Non-toxic Cationic α-Helical Antimicrobial Peptide Against Antibiotic-Resistant ESKAPE Pathogens. | Front Microbiol | 2021
Evidence 7 Activity

Activity

2% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
2% Hemolysis | 4 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella. | Molecules | 2021
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
67.09 µM
Hemolytic Cytotoxic
50% Hemolysis | 67.09 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella. | Molecules | 2021
Evidence 9 Activity

Activity

0.7% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
0.7% Hemolysis | 8 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella. | Molecules | 2021
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
886.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 886.5 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella. | Molecules | 2021