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Peptide record

TPDB17045

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB17045
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FIKAIARLLRKIF
Physicochemical Analysis
C78H133N21O14
NDCEQGHMPSTWYV
I
1589.05
12.42
4
0
9
+4
-1.05
1.038
165.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C78H133N21O14
1589.05
12.42
+4
-1.05
1.038
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Staphylococcus aureus ATCC 29212

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus ATCC 29212 (MIC 10 ug/ml) and E. coli ATCC 25922 (MIC 20 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

active against S. aureus ATCC 29212 (MIC 10 ug/ml) and E. coli ATCC 25922 (MIC 20 ug/ml).
Evidence 3 Activity

Activity

77.5% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
77.5% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fine-Tuning of Alkaline Residues on the Hydrophilic Face Provides a Non-toxic Cationic α-Helical Antimicrobial Peptide Against Antibiotic-Resistant ESKAPE Pathogens. | Front Microbiol | 2021