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Peptide record

TPDB16948

Antibacterial Anticancer Toxicity standard

13 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB16948

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.

Sequence

IRIILRAQGALKI

FASTA

>TPDB16948|Antibacterial;Anticancer;Toxicity|length=13
IRIILRAQGALKI

Formula C67H125N21O15

Absent Amino Acids NDCEHMFPSTWYV

Common Amino Acids I

Mass 1464.86

PI 12.41

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +3

Boman Index 0.50

Hydrophobicity 0.954

Aliphatic Index 195.38

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 4 L: 2 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C67H125N21O15

Mass

1464.86

12.41

Net Charge

Boman Index

0.50

Hydrophobicity

0.954

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism S. Faecalis

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against both Gram+ and Gram- bacteria. Active against Gram+ S. Faecalis (MIC 50 ug/ml), S. pyogenes ATCC 14289 (MIC 50 ug/ml), S. aureus ATCC 6538 or ATCC 29213 or MRSA ATCC BA

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Streptococcus pyogenes ATCC 14289

Source & Reference

Database Source dbAMP

Other

Evidence Text

e against both Gram+ and Gram- bacteria. Active against Gram+ S. Faecalis (MIC 50 ug/ml), S. pyogenes ATCC 14289 (MIC 50 ug/ml), S. aureus ATCC 6538 or ATCC 29213 or MRSA ATCC BAA-41 or 44 (MIC 20-64 ug/ml), S. epider

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20-64 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 6538 or ATCC 29213 or MRSA ATCC BAA-41 or 44

Source & Reference

Database Source dbAMP

Other

Evidence Text

. Active against Gram+ S. Faecalis (MIC 50 ug/ml), S. pyogenes ATCC 14289 (MIC 50 ug/ml), S. aureus ATCC 6538 or ATCC 29213 or MRSA ATCC BAA-41 or 44 (MIC 20-64 ug/ml), S. epidermidis ATCC 12228 (MIC 4 ug/ml), B. subtilis 168 (MIC 16 ug/ml), Gram- bacteria

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source dbAMP

Other

Evidence Text

50 ug/ml), S. aureus ATCC 6538 or ATCC 29213 or MRSA ATCC BAA-41 or 44 (MIC 20-64 ug/ml), S. epidermidis ATCC 12228 (MIC 4 ug/ml), B. subtilis 168 (MIC 16 ug/ml), Gram- bacteria A. hydrophila ATCC 49140 (MIC 20 ug/ml),

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism B. subtilis 168

Source & Reference

Database Source dbAMP

Other

Evidence Text

213 or MRSA ATCC BAA-41 or 44 (MIC 20-64 ug/ml), S. epidermidis ATCC 12228 (MIC 4 ug/ml), B. subtilis 168 (MIC 16 ug/ml), Gram- bacteria A. hydrophila ATCC 49140 (MIC 20 ug/ml), V. alginolyticus ATCC 33840 (MIC

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µg/mL

Target

Target Organism A. hydrophila ATCC 49140

Source & Reference

Database Source dbAMP

Other

Evidence Text

, S. epidermidis ATCC 12228 (MIC 4 ug/ml), B. subtilis 168 (MIC 16 ug/ml), Gram- bacteria A. hydrophila ATCC 49140 (MIC 20 ug/ml), V. alginolyticus ATCC 33840 (MIC 50 ug/ml), E. tarda PE210 (MIC 10 ug/ml), E. cloacae BA

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism V. alginolyticus ATCC 33840

Source & Reference

Database Source dbAMP

Other

Evidence Text

, B. subtilis 168 (MIC 16 ug/ml), Gram- bacteria A. hydrophila ATCC 49140 (MIC 20 ug/ml), V. alginolyticus ATCC 33840 (MIC 50 ug/ml), E. tarda PE210 (MIC 10 ug/ml), E. cloacae BAA-1143 (MIC 32 ug/ml), A. baumannii ATCC 196

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism E. tarda PE210

Source & Reference

Database Source dbAMP

Other

Evidence Text

eria A. hydrophila ATCC 49140 (MIC 20 ug/ml), V. alginolyticus ATCC 33840 (MIC 50 ug/ml), E. tarda PE210 (MIC 10 ug/ml), E. cloacae BAA-1143 (MIC 32 ug/ml), A. baumannii ATCC 19606 (MIC 10 ug/ml), E. coli ATCC

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism Enterobacter cloacae BAA-1143

Source & Reference

Database Source dbAMP

Other

Evidence Text

MIC 20 ug/ml), V. alginolyticus ATCC 33840 (MIC 50 ug/ml), E. tarda PE210 (MIC 10 ug/ml), E. cloacae BAA-1143 (MIC 32 ug/ml), A. baumannii ATCC 19606 (MIC 10 ug/ml), E. coli ATCC 10536 or pathogenic E. coli (MIC 5

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source dbAMP

Other

Evidence Text

33840 (MIC 50 ug/ml), E. tarda PE210 (MIC 10 ug/ml), E. cloacae BAA-1143 (MIC 32 ug/ml), A. baumannii ATCC 19606 (MIC 10 ug/ml), E. coli ATCC 10536 or pathogenic E. coli (MIC 5 ug/ml), E. coli BL21 (DE3) (MIC 8 ug/ml)

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 32 ug/ml), A. baumannii ATCC 19606 (MIC 10 ug/ml), E. coli ATCC 10536 or pathogenic E. coli (MIC 5 ug/ml), E. coli BL21 (DE3) (MIC 8 ug/ml), K. pneumoniae (NDM-1) ATCC BAA-2470 (MIC 32 ug/ml), E.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Pseudomonas aeruginosa A

Source & Reference

Database Source dbAMP

Other

Evidence Text

L21 (DE3) (MIC 4 ug/ml), TEM-1/BL21 (DE3) (MIC 8 ug/ml), MCR-1/BL21 (DE3) (MIC 16 ug/ml), P. aeruginosa A (MIC 50 ug/ml). Reg. 7/2021

Evidence 13 Activity

Activity

Activity Endpoint 25% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

25% Killing | 100 | µg/mL | target cell: Mouse osteoblastic cells MC3T3-E1

Target

Target Cell Mouse osteoblastic cells MC3T3-E1

Source & Reference

Database Source NA

Source Database DBAASP

Reference

BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression | Sci Rep | 2021

Evidence 14 Activity

Activity

Activity Endpoint 20% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

20% Killing | 100 | µg/mL | target cell: Human skin fibroblasts AG06858

Target

Target Cell Human skin fibroblasts AG06858

Source & Reference

Database Source NA

Source Database DBAASP

Reference

BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression | Sci Rep | 2021

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Sci Rep. 2021 Jun 9 11(1):12219.