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Peptide record

TPDB16945

Antibacterial Anticancer Antiparasitic Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB16945
Antibacterial Anticancer Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
YNKKYRYHLKSCKKADK
Physicochemical Analysis
C98H157N29O25S1
EQGIMFPTWV
K
2173.56
10.30
8
1
5
+6
5.70
-2.041
28.82
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
4470
205.65
6
Residue Composition
number
1
A
1
R
1
N
1
D
1
C
0
E
0
Q
0
G
1
H
0
I
1
L
6
K
0
M
0
F
0
P
1
S
0
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 3 V: 0
Chemical Descriptors
17
C98H157N29O25S1
2173.56
10.30
+6
5.70
-2.041
Evidence Records 3 records
Evidence 1 Activity

Activity

<3% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
<3% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dissection of phospholipases A 2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria. | Bioorg Chem | 2021
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
550.83 µM
Cytotoxic
50% Cytotoxicity | 550.83 | µM | target cell: Bone marrow-derived macrophages (BMDMs)

Target

Bone marrow-derived macrophages (BMDMs)

Source & Reference

NA
DBAASP
Dissection of phospholipases A 2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria. | Bioorg Chem | 2021
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Chem. 2021 Sep 114:105043.