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Peptide record

TPDB16944

Antibacterial Anticancer Antiparasitic Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB16944
Antibacterial Anticancer Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
YNKKYMKHLKPCKKA
Physicochemical Analysis
C86H142N24O19S2
RDEQGIFSTWV
K
1880.34
10.43
7
0
5
+6
4.69
-1.620
32.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
158.48
4
Residue Composition
number
1
A
0
R
1
N
0
D
1
C
0
E
0
Q
0
G
1
H
0
I
1
L
6
K
1
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 6 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
15
C86H142N24O19S2
1880.34
10.43
+6
4.69
-1.620
Evidence Records 3 records
Evidence 1 Activity

Activity

<3% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
<3% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dissection of phospholipases A 2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria. | Bioorg Chem | 2021
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
492 µM
Cytotoxic
50% Cytotoxicity | 492 | µM | target cell: Bone marrow-derived macrophages (BMDMs)

Target

Bone marrow-derived macrophages (BMDMs)

Source & Reference

NA
DBAASP
Dissection of phospholipases A 2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria. | Bioorg Chem | 2021
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Chem. 2021 Sep 114:105042.