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Peptide record

TPDB16943

Antibacterial Anticancer Antiparasitic Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16943
Antibacterial Anticancer Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
NLRTYKKRYMFY
Physicochemical Analysis
C79H119N21O18S1
ADCEQGHIPSWV
Y
1683.00
10.47
4
0
6
+4
-0.58
-1.367
32.50
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
4470
265.60
5
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
2
K
1
M
1
F
0
P
0
S
1
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 2 M: 1 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 3 V: 0
Chemical Descriptors
12
C79H119N21O18S1
1683.00
10.47
+4
-0.58
-1.367
Evidence Records 3 records
Evidence 1 Activity

Activity

<3% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
<3% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dissection of phospholipases A 2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria. | Bioorg Chem | 2021
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
448 µM
Cytotoxic
50% Cytotoxicity | 448 | µM | target cell: Bone marrow-derived macrophages (BMDMs)

Target

Bone marrow-derived macrophages (BMDMs)

Source & Reference

NA
DBAASP
Dissection of phospholipases A 2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria. | Bioorg Chem | 2021
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Chem. 2021 Sep 114:105041.