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Peptide record

TPDB16935

Antibacterial Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB16935
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 8-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
RRRWWWWV
Physicochemical Analysis
C67H87N21O9
ANDCEQGHILKMFPSTY
W
1330.56
12.70
3
0
5
+3
-4.90
-1.612
36.25
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1653.44
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 1
Chemical Descriptors
8
C67H87N21O9
1330.56
12.70
+3
-4.90
-1.612
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

E. faecium V286-17

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram+ pathogens, verine is active against both Gram+ and Gram- pathogens, E. faecium V286-17 (MIC 2 uM) anti-VRE, S. aureus USA300 LAC MRSA and 30 clinical strains (MIC 2-8 uM), K. pneumoniae E
Evidence 2 Activity

Activity

MIC
Antibacterial
2-8 µM

Target

Staphylococcus aureus USA300 LAC MRSA and 30 clinical strains

Source & Reference

dbAMP

Other

is active against both Gram+ and Gram- pathogens, E. faecium V286-17 (MIC 2 uM) anti-VRE, S. aureus USA300 LAC MRSA and 30 clinical strains (MIC 2-8 uM), K. pneumoniae E406-17 and 22 clinical strains (MIC 4-32 uM), A. baumannii B28-16 (MIC 8
Evidence 3 Activity

Activity

MIC
Antibacterial
4-32 µM

Target

Klebsiella pneumoniae E406-17 and 22 clinical strains

Source & Reference

dbAMP

Other

6-17 (MIC 2 uM) anti-VRE, S. aureus USA300 LAC MRSA and 30 clinical strains (MIC 2-8 uM), K. pneumoniae E406-17 and 22 clinical strains (MIC 4-32 uM), A. baumannii B28-16 (MIC 8 uM), P. aeruginosa E411-17 (4-8 uM), and E. coli E423-17 (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

A. baumannii B28-16

Source & Reference

dbAMP

Other

inical strains (MIC 2-8 uM), K. pneumoniae E406-17 and 22 clinical strains (MIC 4-32 uM), A. baumannii B28-16 (MIC 8 uM), P. aeruginosa E411-17 (4-8 uM), and E. coli E423-17 (MIC 2 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli E423-17

Source & Reference

dbAMP

Other

trains (MIC 4-32 uM), A. baumannii B28-16 (MIC 8 uM), P. aeruginosa E411-17 (4-8 uM), and E. coli E423-17 (MIC 2 uM).
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
130 µM
Hemolytic Cytotoxic
50% Hemolysis | 130 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020
Evidence 7 Activity

Activity

LD50
Toxicity
>80 µM
Cytotoxic
LD50 | >80 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020
Evidence 8 Activity

Activity

LD50
Toxicity
>80 µM
Cytotoxic
LD50 | >80 | µM | target cell: Human hepatocyte cells HepaRG

Target

Human hepatocyte cells HepaRG

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020
Evidence 9 Activity

Activity

LD50
Toxicity
>25 µM
Cytotoxic
LD50 | >25 | µM | target cell: Human lung fibroblasts MRC-9

Target

Human lung fibroblasts MRC-9

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020
Evidence 10 Activity

Activity

LD50
Toxicity
12.5 µM
Cytotoxic
LD50 | 12.5 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020