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Peptide record

TPDB16929

Antibacterial Anticancer Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB16929
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
KWWKKWKKWW
Physicochemical Analysis
C85H112N20O11
ARNDCEQGHILMFPSTYV
KW
1589.95
11.12
5
0
5
+5
-4.30
-2.400
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
1729.61
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
10
C85H112N20O11
1589.95
11.12
+5
-4.30
-2.400
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
134.38 µM
Hemolytic Cytotoxic
10% Hemolysis | 134.38 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. | J Med Chem | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
40.25 µM
Cytotoxic
IC50 | 40.25 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Human glomerular mesangial cells (GMC)

Source & Reference

NA
DBAASP
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. | J Med Chem | 2021
Evidence 3 Activity

Activity

IC50
Toxicity
63.52 µM
Cytotoxic
IC50 | 63.52 | µM | target cell: Human kidney proximal tubule HK-2 cells

Target

Human kidney proximal tubule HK-2 cells

Source & Reference

NA
DBAASP
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. | J Med Chem | 2021
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2021 Aug 12 64(15):11247-11266.