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Peptide record

TPDB16925

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB16925
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
KWWKRWKKWW
Physicochemical Analysis
C85H112N22O11
ANDCEQGHILMFPSTYV
W
1617.97
11.80
5
0
5
+5
-4.48
-2.460
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
1699.67
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
10
C85H112N22O11
1617.97
11.80
+5
-4.48
-2.460
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
77.65 µM
Hemolytic Cytotoxic
10% Hemolysis | 77.65 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. | J Med Chem | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
19.77 µM
Cytotoxic
IC50 | 19.77 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Human glomerular mesangial cells (GMC)

Source & Reference

NA
DBAASP
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. | J Med Chem | 2021