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Peptide record

TPDB16909

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB16909
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 10-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
GAAKRAKTAA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C39H73N15O12
NDCEQHILMFPSWYV
A
944.10
11.64
3
0
5
+3
1.86
-0.440
50.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
5
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
10 reviewed residue count
C39H73N15O12 sequence-only estimate (linear, free termini)
944.10 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
1.86 sequence-only estimate (linear, free termini)
-0.440 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>=512 µM
Hemolytic Cytotoxic
10% Hemolysis | >=512 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. | J Med Chem | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
>=512 µM
Cytotoxic
IC50 | >=512 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Human glomerular mesangial cells (GMC)

Source & Reference

NA
DBAASP
Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. | J Med Chem | 2021