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Peptide record

TPDB16890

Pugnin B Antibacterial Anticancer Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB16890
Pugnin B
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from dbAMP, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
RMMRIFWVIKLAR
Physicochemical Analysis
C80H134N24O14S2
NDCEQGHPSTY
R
1720.22
12.71
4
0
9
+4
-1.30
0.546
120.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
319.73
0
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
1
K
2
M
1
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 1 M: 2 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C80H134N24O14S2
1720.22
12.71
+4
-1.30
0.546
Free
L
Linear
Free
Antibacterial and Anticancer
Synthetic Using Skin Transcriptome of Treefrog ( Boana pugnax)
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC50
Antibacterial
18.0 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus ATCC 25923 (MIC50 9.2 uM, MIC90 549.7 uM), E. faecalis ATCC 29212 (MIC50 18.0 uM), MIC90 111.2 uM), P. aeruginosa ATCC 27853 (MIC50 8.9 uM MIC90 158.4 uM), E. coli ATCC 2
Evidence 2 Activity

Activity

5% Cytotoxicity at 100 µM
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

90% Cytotoxicity at 100 µM
Anticancer

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
50% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Silico Selection and Evaluation of Pugnins with Antibacterial and Anticancer Activity Using Skin Transcriptome of Treefrog ( Boana pugnax). | Pharmaceutics | 2021
Evidence 5 Activity

Activity

13% Cytotoxicity
Toxicity
100 µM
Cytotoxic
13% Cytotoxicity | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
In Silico Selection and Evaluation of Pugnins with Antibacterial and Anticancer Activity Using Skin Transcriptome of Treefrog ( Boana pugnax). | Pharmaceutics | 2021
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Pharmaceutics. 2021 Apr 18 13(4):579.
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis