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Peptide record

TPDB16844

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16844
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 12-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
DVATSARDPLFY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C61H91N15O20
NCEQGHIKMW
AD
1354.48
3.88
1
2
6
-1
1.91
-0.125
73.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
1.10
3
Residue Composition
number
2
A
1
R
0
N
2
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
12 reviewed residue count
C61H91N15O20 sequence-only estimate (linear, free termini)
1354.48 sequence-only estimate (linear, free termini)
3.88 sequence-only estimate (linear, free termini)
-1 sequence-only estimate (linear, free termini)
1.91 sequence-only estimate (linear, free termini)
-0.125 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
124 µM
Hemolytic Cytotoxic
0% Hemolysis | 124 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp. | J Proteomics | 2021
Evidence 2 Activity

Activity

20% Killing
Toxicity
100 µM
Cytotoxic
20% Killing | 100 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Encrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp. | J Proteomics | 2021