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Peptide record

TPDB16839

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB16839
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FYTHVFRLKKWIQKVIDQFGE
Physicochemical Analysis
C130H192N32O30
ANCMPS
KF
2683.15
10.06
5
2
10
+2
2.08
-0.338
83.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
260.51
4
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
1
E
2
Q
1
G
1
H
2
I
1
L
3
K
0
M
3
F
0
P
0
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 1 H: 1 I: 2 L: 1 K: 3 M: 0 F: 3 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
21
C130H192N32O30
2683.15
10.06
+2
2.08
-0.338
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
zone inhibition: active against E. coli, P. aeruginosa, S. aureus, and C. albicans.
Evidence 2 Activity

Activity

43.4% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
43.4% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria. | Molecules | 2021