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Peptide record

TPDB16838

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16838
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 12-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
VFRLKKWIQKVI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C77H128N20O14
ANDCEGHMPSTY
K
1557.99
11.73
4
0
7
+4
0.75
0.283
145.83
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
3.53
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
3
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
12 reviewed residue count
C77H128N20O14 sequence-only estimate (linear, free termini)
1557.99 sequence-only estimate (linear, free termini)
11.73 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.75 sequence-only estimate (linear, free termini)
0.283 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
80-160 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
zone inhibition: active against E. coli (MIC 80-160 uM), P. aeruginosa, S.aureus (MIC 160 uM), and C. albicans.
Evidence 2 Activity

Activity

MIC
Antibacterial
160 µM

Target

S.aureus

Source & Reference

dbAMP

Other

zone inhibition: active against E. coli (MIC 80-160 uM), P. aeruginosa, S.aureus (MIC 160 uM), and C. albicans.
Evidence 3 Activity

Activity

0.1% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0.1% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria. | Molecules | 2021
Evidence 4 Activity

Activity

0.2% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0.2% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria. | Molecules | 2021
Evidence 5 Activity

Activity

4% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria. | Molecules | 2021
Evidence 6 Activity

Activity

4.6% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
4.6% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria. | Molecules | 2021