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Peptide record

TPDB16808

Antibacterial Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB16808
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
GVIIDTLKGAAKTVAAELLRKAH
Physicochemical Analysis
C106H187N31O30
NCQMFPSWY
A
2375.84
10.31
5
2
12
+2
5.28
0.400
131.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
5
A
1
R
0
N
1
D
0
C
1
E
0
Q
2
G
1
H
2
I
3
L
3
K
0
M
0
F
0
P
0
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 1 I: 2 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C106H187N31O30
2375.84
10.31
+2
5.28
0.400
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
16393 µM
Hemolytic Cytotoxic
50% Hemolysis | 16393 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Study on the Structure-Activity Relationship of an Antimicrobial Peptide, Brevinin-2GUb, from the Skin Secretion of Hylarana guentheri. | Antibiotics (Basel) | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
381.6 µM
Cytotoxic
IC50 | 381.6 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Study on the Structure-Activity Relationship of an Antimicrobial Peptide, Brevinin-2GUb, from the Skin Secretion of Hylarana guentheri. | Antibiotics (Basel) | 2021