Back to search

Peptide record

TPDB16778

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) W1b (Linear Tri-Trp) Antibacterial iDPPIV Selfassembly standard
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB16778
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) W1b (Linear Tri-Trp)
Antibacterial iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Self-assembling and biomaterial peptides
dbAMP iDPPIV Peptipedia SAPdb
standard
No
A 3-aa standard natural multi-activity (Antibacterial, iDPPIV, and Selfassembly) peptide sequence curated from dbAMP, iDPPIV, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WWW
Physicochemical Analysis
C33H32N6O4
ARNDCEQGHILKMFPSTYV
W
576.65
6.02
0
0
3
-0
-5.55
-0.900
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
2861.33
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
3
C33H32N6O4
576.65
6.02
-0
-5.55
-0.900
576.6437
576.2478
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

26631316
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanosphere Spherical structure
solvent: Methanol:chloroform (1:1) concentration: 2.54mM
Selfassembly; Nanostructure=Nanosphere; Spherical structure; Trigger=solvent: Methanol:chloroform (1:1); concentration: 2.54mM
Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
Selfassembly
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
iDPPIV
216.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derivedpeptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51, 2014
2014
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C33H32N6O4/c34-25(13-19-16-35-26-10-4-1-7-22(19)26)31(40)38-29(14-20-17-36-27-11-5-2-8-23(20)27)32(41)39-30(33(42)43)15-21-18-37-28-12-6-3-9-24(21)28/h1-12,16-18,25,29-30,35-37H,13-15,34H2,(H,38,40)(H,39,41)(H,42,43)/t25-,29-,30-/m0/s1 InChIKey=KRCAKIVDAFTTGJ-ARVREXMNSA-N Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides the EROP-Moscow database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 343)
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanosphere Spherical structure Trigger=solvent: Methanol:chloroform (1:1) concentration: 2.54mM
Nanosphere Spherical structure

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
solvent: Methanol:chloroform (1:1) concentration: 2.54mM
Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and AFM (Atomic Force Microscopy)
26631316
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
solvent: Methanol:chloroform (1:1) concentration: 2.54mM
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
3
26631316
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly