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Peptide record

TPDB16737

Antibacterial Hemolysis Toxicity standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB16737
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia PD_Hemolysis
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
WRWWR
Physicochemical Analysis
C45H56N14O6
ANDCEQGHILKMFPSTYV
W
889.03
12.40
2
0
3
+2
-3.93
-2.340
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
1855.96
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
5
C45H56N14O6
889.03
12.40
+2
-3.93
-2.340
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
60 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 60 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial evaluation of structurally amphipathic, membrane active small cationic peptidomimetics: synthesized by incorporating 3-amino benzoic acid as peptidomimetic element. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial evaluation of structurally amphipathic, membrane active small cationic peptidomimetics: synthesized by incorporating 3-amino benzoic acid as peptidomimetic element. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

50% Cell death
Toxicity
100 µg/mL
Cytotoxic
50% Cell death | 100 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antibacterial evaluation of structurally amphipathic, membrane active small cationic peptidomimetics: synthesized by incorporating 3-amino benzoic acid as peptidomimetic element. | Eur J Med Chem | 2014
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis