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Peptide record

TPDB16694

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Antifungal Hemolysis Toxicity iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB16694
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Antifungal Hemolysis Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb PD_Hemolysis iDPPIV
standard
No
A 3-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
WRR
Physicochemical Analysis
C23H36N10O4
ANDCEQGHILKMFPSTYV
R
516.60
12.40
2
0
1
+2
-0.23
-3.300
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1064.65
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C23H36N10O4
516.60
12.40
+2
-0.23
-3.300
516.5951
516.2914
Evidence Records 9 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
10% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
42.42 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 42.42 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
10% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
36.91 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 36.91 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
10% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
10% Hemolysis | 32 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021
Evidence 8 Activity

Activity

IC50
iDPPIV
570.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ito S., Kawarasaki Y.
Trp-Arg-Xaa tripeptides act as uncompetitive-type inhibitors of human dipeptidyl peptidase IV. Peptides, 54, 166-170
2014
Journal

Other

3
Evidence 9 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis
Additional Detail Fields 1 fields
3