TPDB

3D PDB MODEL

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TPDB ID TPDB16618

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and PD_Hemolysis, with an available 3D structural model.

Sequence

RRW

FASTA

>TPDB16618|Antibacterial;Hemolysis;Toxicity|length=3
RRW

Formula C23H36N10O4

Absent Amino Acids ANDCEQGHILKMFPSTYV

Common Amino Acids R

Mass 516.60

PI 12.40

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +2

Boman Index -0.23

Hydrophobicity -3.300

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 1064.65

Polar Residues 0

number

0

A

2

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

3

Formula

C23H36N10O4

Mass

516.60

PI

12.40

Net Charge

+2

Boman Index

-0.23

Hydrophobicity

-3.300

Evidence 1 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 2 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 128 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 3 Activity

Activity

Activity Endpoint 45% Killing

Detail Source Activity Toxicity

Activity Measurement 64 µM

Toxicity Type Cytotoxic

Toxicity Raw

45% Killing | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Target Cell Human embryonic kidney HEK293T cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 4 Activity

Activity

Activity Endpoint 80% Killing

Detail Source Activity Toxicity

Activity Measurement 128 µM

Toxicity Type Cytotoxic

Toxicity Raw

80% Killing | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Target Cell Human embryonic kidney HEK293T cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 5 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 32 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance. | Eur J Med Chem | 2021

Evidence 6 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis