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Peptide record

TPDB16599

R7 Antibacterial Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB16599
R7
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 7-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
Sequence
RRRRRWW
Physicochemical Analysis
C52H82N24O8
ANDCEQGHILKMFPSTYV
R
1171.38
13.00
5
0
2
+5
0.35
-3.471
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
939.06
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
7
C52H82N24O8
1171.38
13.00
+5
0.35
-3.471
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , L929, Hct, A594, Hep-G2 And Hsc Cells

Assay & Model

Female BALB/c mice (4−6 weeks 23 old and weighing 18−22 g)
Female BALB/c mice (4−6 weeks 23 old and weighing 18−22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC-labeled and Paclitaxel (PTX)
Cytoplasm and nucleus
Green fluorescence was observed for all tested R7 concentrations, whereas there was no visible green fluorescence for the untreated cells and the cells incubated with FITC only and the penetration rate of PTX is much faster with the help of R7 than PTX alone.
Direct translocation and clathrin-dependent endocytosis
In vitro and in vivo
CCCCCCCCTTCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCTTCCCCCCCC