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Peptide record

TPDB16570

Antibacterial Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB16570
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 9-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
WRRWWWRRW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C79H100N26O10
ANDCEQGHILKMFPSTYV
W
1573.83
12.88
4
0
5
+4
5.34
-2.500
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
27500
17.47
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
9 reviewed residue count
C79H100N26O10 sequence-only estimate (linear, free termini)
1573.83 sequence-only estimate (linear, free termini)
12.88 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
5.34 sequence-only estimate (linear, free termini)
-2.500 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

13% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
13% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance. | Biochem Pharmacol | 2021
Evidence 2 Activity

Activity

30% Killing
Toxicity
128 µM
Cytotoxic
30% Killing | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance. | Biochem Pharmacol | 2021