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Peptide record

TPDB16549

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16549
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
WRKWRKWRKWRK
Physicochemical Analysis
C92H138N32O13
ANDCEQGHILMFPSTYV
RKW
1900.31
12.89
8
0
4
+8
-0.20
-3.100
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
1157.70
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
12
C92H138N32O13
1900.31
12.89
+8
-0.20
-3.100
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
10% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
New Antimicrobial Peptides with Repeating Unit against Multidrug-Resistant Bacteria. | ACS Infect Dis | 2021
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>128 µM
Cytotoxic
50% Cell death | >128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
New Antimicrobial Peptides with Repeating Unit against Multidrug-Resistant Bacteria. | ACS Infect Dis | 2021