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Peptide record

TPDB16531

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB16531
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
GKLRLIKKLWVKKWKKKGWKA
Physicochemical Analysis
C129H216N36O22
NDCEQHMFPSTY
K
2623.36
12.00
10
0
9
+10
2.10
-1.010
92.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16500
628.96
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
3
L
9
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 3 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
21
C129H216N36O22
2623.36
12.00
+10
2.10
-1.010
Evidence Records 4 records
Evidence 1 Activity

Activity

3.7% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
3.7% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dual antimicrobial and anticancer activity of a novel synthetic α-helical antimicrobial peptide. | Eur J Pharm Sci | 2021
Evidence 2 Activity

Activity

25.9% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
25.9% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dual antimicrobial and anticancer activity of a novel synthetic α-helical antimicrobial peptide. | Eur J Pharm Sci | 2021
Evidence 3 Activity

Activity

26.5% Killing
Toxicity
8 µM
Cytotoxic
26.5% Killing | 8 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Dual antimicrobial and anticancer activity of a novel synthetic α-helical antimicrobial peptide. | Eur J Pharm Sci | 2021
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2021 Jun 1 161:105784.