Back to search

Peptide record

TPDB16528

Antibacterial Anticancer Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB16528
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
PWRLRLRL
Physicochemical Analysis
C52H88N18O9
ANDCEQGHIKMFSTYV
RL
1109.39
12.70
3
0
4
+3
-0.65
-0.575
146.25
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
495.77
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
8
C52H88N18O9
1109.39
12.70
+3
-0.65
-0.575
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
<256 µM
Hemolytic Cytotoxic
<5% Hemolysis | <256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo. | Eur J Med Chem | 2021
Evidence 2 Activity

Activity

<15% Killing
Toxicity
256 µM
Cytotoxic
<15% Killing | 256 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo. | Eur J Med Chem | 2021
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2021 Jul 5 219:113434.