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Peptide record

TPDB16513

Antibacterial Antifungal Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB16513
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
LWGALLGLGSTLLSKL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C78H132N18O20
RNDCEQHIMFPYV
L
1642.01
10.10
1
0
9
+1
-1.66
1.256
176.88
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
3.35
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
7
L
1
K
0
M
0
F
0
P
2
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 7 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C78H132N18O20 sequence-only estimate (linear, free termini)
1642.01 sequence-only estimate (linear, free termini)
10.10 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-1.66 sequence-only estimate (linear, free termini)
1.256 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
4.8±0.7 µM
Hemolytic Cytotoxic
50% Hemolysis | 4.8±0.7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of NDBP-4 family antimicrobial peptides from the scorpion Mesomexovis variegatus. | Peptides | 2021
Evidence 2 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis