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Peptide record

TPDB16501

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB16501
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
KRIGCWRWRRWPRLRK
Physicochemical Analysis
C103H165N39O17S1
ANDEQHMFSTYV
R
2253.75
12.71
8
0
5
+8
0.64
-1.794
48.75
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
732.11
1
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
1
L
2
K
0
M
0
F
1
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
16
C103H165N39O17S1
2253.75
12.71
+8
0.64
-1.794
Evidence Records 3 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability. | J Pept Sci | 2021
Evidence 2 Activity

Activity

10% Killing
Toxicity
28 µM
Cytotoxic
10% Killing | 28 | µM | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability. | J Pept Sci | 2021
Evidence 3 Activity

Activity

0% Killing
Toxicity
28 µM
Cytotoxic
0% Killing | 28 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability. | J Pept Sci | 2021