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Peptide record

TPDB16444

Antibacterial Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB16444
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GFLDVLKGVGKAALGAVTHLINQGEQ
Physicochemical Analysis
C118H195N33O35
RCMPSWY
G
2636.05
7.79
3
2
12
+0
3.98
0.358
120.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
3
A
0
R
1
N
1
D
0
C
1
E
2
Q
5
G
1
H
1
I
4
L
2
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 2 G: 5 H: 1 I: 1 L: 4 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
26
C118H195N33O35
2636.05
7.79
+0
3.98
0.358
Evidence Records 4 records
Evidence 1 Activity

Activity

9.7% Hemolysis
Toxicity
55.1 µM
Hemolytic Cytotoxic
9.7% Hemolysis | 55.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial cruzioseptin peptides extracted from the splendid leaf frog, Cruziohyla calcarifer. | Amino Acids | 2021
Evidence 2 Activity

Activity

21.8% Hemolysis
Toxicity
110.3 µM
Hemolytic Cytotoxic
21.8% Hemolysis | 110.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial cruzioseptin peptides extracted from the splendid leaf frog, Cruziohyla calcarifer. | Amino Acids | 2021
Evidence 3 Activity

Activity

55.2% Hemolysis
Toxicity
220.6 µM
Hemolytic Cytotoxic
55.2% Hemolysis | 220.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial cruzioseptin peptides extracted from the splendid leaf frog, Cruziohyla calcarifer. | Amino Acids | 2021
Evidence 4 Activity

Activity

IC50
Toxicity
5.59 µM
Cytotoxic
IC50 | 5.59 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana, Plasmodium falciparum, and Trypanosoma cruzi | Microbiol Spectr | 2024