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Peptide record

TPDB16428

Antibacterial Toxicity modified_plain modified
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16428
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
modified_plain
Yes
A 12-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
AKRXXGYKRKFX
Physicochemical Analysis
C53H88N18O11
NDCEQHILMPSTWV
K
1153.40
11.59
5
0
3
+5
2.36
-1.483
8.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1490
129.18
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C53H88N18O11
1153.40
11.59
+5
2.36
-1.483
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Dependence on size and shape of non-nature amino acids in the enhancement of lipopolysaccharide (LPS) neutralizing activities of antimicrobial peptides. | J Colloid Interface Sci | 2019
Evidence 2 Activity

Activity

18% Killing
Toxicity
50 µg/mL
Cytotoxic
18% Killing | 50 | µg/mL | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Dependence on size and shape of non-nature amino acids in the enhancement of lipopolysaccharide (LPS) neutralizing activities of antimicrobial peptides. | J Colloid Interface Sci | 2019
Evidence 3 Activity

Activity

10% Killing
Toxicity
50 µg/mL
Cytotoxic
10% Killing | 50 | µg/mL | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Dependence on size and shape of non-nature amino acids in the enhancement of lipopolysaccharide (LPS) neutralizing activities of antimicrobial peptides. | J Colloid Interface Sci | 2019