TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB16361

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural antibacterial peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.

Sequence

MKRILLKSDRTLDDSELAKVIGGGFFEGIGRWIDQRWH

FASTA

>TPDB16361|Antibacterial|length=38
MKRILLKSDRTLDDSELAKVIGGGFFEGIGRWIDQRWH

Formula C200H316N58O55S1

Absent Amino Acids NCPY

Common Amino Acids G

Mass 4445.12

PI 9.75

Basic Residues 8

Acidic Residues 6

Hydrophobic Residues 15

Net Charge +1

Boman Index 7.39

Hydrophobicity -0.442

Aliphatic Index 92.37

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 11000

Absorbance 280nm 247.46

Polar Residues 4

number

1

A

4

R

0

N

4

D

0

C

2

E

1

Q

5

G

1

H

4

I

4

L

3

K

1

M

2

F

0

P

2

S

1

T

2

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 4 N: 0 D: 4 C: 0 E: 2 Q: 1 G: 5 H: 1 I: 4 L: 4 K: 3 M: 1 F: 2 P: 0 S: 2 T: 1 W: 2 Y: 0 V: 1

Length

38

Formula

C200H316N58O55S1

Mass

4445.12

PI

9.75

Net Charge

+1

Boman Index

7.39

Hydrophobicity

-0.442

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Diffusion zone assay: active against Gram+ S. aureus ATCC 29213, 25923 (15.9-16.0 mm), E.faecalis ATCC 29212 (0 mm), L. monocytogenes CMCC 54004 (12.8 mm), Gram- E. coli ATCC 25922 (13 mm), Salmonella CMCC 50071 (17 mm), C. sakazakii ATCC 29544 (16.1 mm), also active against antibiotic0resistant C. sakazakii (15.0-16.8 mm) and Salmonella 557D (13.1 mm). Reg. 11/2021