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Peptide record

TPDB16300

PEP-NJSM Antibacterial Cell-penetrating Peptides Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB16300
PEP-NJSM
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
dbAMP Peptipedia CPPsite3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CPPsite3.0, with an available 3D structural model.
Sequence
RYAKMKRRRRRVARRHRRR
Physicochemical Analysis
C109H202N56O21S1
NDCEQGILFPSTW
R
2665.23
13.06
14
0
5
+13
10.41
-2.742
25.79
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
55.91
1
Residue Composition
number
2
A
11
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
2
K
1
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 11 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 2 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
19
C109H202N56O21S1
2665.23
13.06
+13
10.41
-2.742
Free
L
Cationic
Linear
Free
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Staphylococcus Epidermidis And Pseudomonas Aeruginosa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Synthetic
In vitro
Evidence 2 Activity

Activity

12% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
12% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The novel cationic cell-penetrating peptide PEP-NJSM is highly active against Staphylococcus epidermidis biofilm. | Int J Biol Macromol | 2019
Evidence 3 Activity

Activity

IC50
Toxicity
292 µM
Cytotoxic
IC50 | 292 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
The novel cationic cell-penetrating peptide PEP-NJSM is highly active against Staphylococcus epidermidis biofilm. | Int J Biol Macromol | 2019