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Peptide record

TPDB16271

Antibacterial Anticancer Antiviral Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB16271
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia DRAVP 2.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from dbAMP, Peptipedia, and DRAVP 2.0, with an available 3D structural model.
Sequence
MGRFKRFRKKFKKLFKKLS
Physicochemical Analysis
C118H197N35O21S1
ANDCEQHIPTWYV
K
2474.14
12.73
10
0
7
+10
3.63
-1.121
41.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
7
K
1
M
4
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 7 M: 1 F: 4 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C118H197N35O21S1
2474.14
12.73
+10
3.63
-1.121
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against V. parahaemolyticus, Gram+ 4 strains S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 19
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

B. megaterium Bm 11

Source & Reference

dbAMP

Other

active against V. parahaemolyticus, Gram+ 4 strains S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. fae
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. subtilis KCTC 3068

Source & Reference

dbAMP

Other

parahaemolyticus, Gram+ 4 strains S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP

Other

S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S
Evidence 5 Activity

Activity

MIC
Antibacterial
8->32 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 stra
Evidence 6 Activity

Activity

MIC
Antibacterial
8->32 µM

Target

E. faecium

Source & Reference

dbAMP

Other

), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 s
Evidence 7 Activity

Activity

MIC
Antibacterial
1-4 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP

Other

), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhim
Evidence 8 Activity

Activity

MIC
Antibacterial
0.5-16 µM

Target

A. baumannii

Source & Reference

dbAMP

Other

strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC
Evidence 9 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

ains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens
Evidence 10 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP

Other

C 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albica
Evidence 11 Activity

Activity

MIC
Antibacterial
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

ii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4
Evidence 12 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP

Other

(MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4 uM). Resistant strains: but Vancomyc
Evidence 13 Activity

Activity

MIC
Antibacterial
16 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4 uM). Resistant strains: but Vancomycin-resistant S-aureus (MIC > 50
Evidence 14 Activity

Activity

MIC
Antibacterial
4 µM

Target

C. neoformans

Source & Reference

dbAMP

Other

ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4 uM). Resistant strains: but Vancomycin-resistant S-aureus (MIC > 50 uM), E-coli ESBL (MIC > 5
Evidence 15 Activity

Activity

MIC
Antiviral
2-4 µM

Target

Staphylococcus aureus

Source & Reference

DRAVP 2.0

Other

active against V. parahaemolyticus, Gram+ 4 strains S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 19
Evidence 16 Activity

Activity

MIC
Antiviral
2 µM

Target

B. megaterium Bm 11

Source & Reference

DRAVP 2.0

Other

active against V. parahaemolyticus, Gram+ 4 strains S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. fae
Evidence 17 Activity

Activity

MIC
Antiviral
4 µM

Target

B. subtilis KCTC 3068

Source & Reference

DRAVP 2.0

Other

parahaemolyticus, Gram+ 4 strains S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E
Evidence 18 Activity

Activity

MIC
Antiviral
4 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

DRAVP 2.0

Other

S. aureus (MIC 2-4 uM), B. megaterium Bm 11 (MIC 2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S
Evidence 19 Activity

Activity

MIC
Antiviral
8->32 µM

Target

Enterococcus faecalis

Source & Reference

DRAVP 2.0

Other

2 uM), B. subtilis KCTC 3068 (MIC 4 uM), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 stra
Evidence 20 Activity

Activity

MIC
Antiviral
8->32 µM

Target

E. faecium

Source & Reference

DRAVP 2.0

Other

), S. epidermidis KCTC 1917 (MIC 4 uM), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 s
Evidence 21 Activity

Activity

MIC
Antiviral
1-4 µM

Target

Streptococcus agalactiae

Source & Reference

DRAVP 2.0

Other

), 10 strains E. faecalis (MIC 8- >32 uM), 5 strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhim
Evidence 22 Activity

Activity

MIC
Antiviral
0.5-16 µM

Target

A. baumannii

Source & Reference

DRAVP 2.0

Other

strains E. faecium (MIC 8->32 uM), 3 strains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC
Evidence 23 Activity

Activity

MIC
Antiviral
2-4 µM

Target

Escherichia coli

Source & Reference

DRAVP 2.0

Other

ains S. agalactiae (MIC 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens
Evidence 24 Activity

Activity

MIC
Antiviral
4 µM

Target

S. typhimurium ATCC 14028

Source & Reference

DRAVP 2.0

Other

C 1-4 uM), Gram- 10 strains A. baumannii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albica
Evidence 25 Activity

Activity

MIC
Antiviral
1 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAVP 2.0

Other

ii (MIC 0.5-16 uM), 3 strains E. coli (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4
Evidence 26 Activity

Activity

MIC
Antiviral
2 µM

Target

S. marcescens ATCC 8100

Source & Reference

DRAVP 2.0

Other

(MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4 uM). Resistant strains: but Vancomyc
Evidence 27 Activity

Activity

MIC
Antiviral
16 µM

Target

Candida albicans

Source & Reference

DRAVP 2.0

Other

MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4 uM). Resistant strains: but Vancomycin-resistant S-aureus (MIC > 50
Evidence 28 Activity

Activity

MIC
Antiviral
4 µM

Target

C. neoformans

Source & Reference

DRAVP 2.0

Other

ATCC 27853 (MIC 1 uM), S. marcescens ATCC 8100 (MIC 2 uM), fungi C. albicans (MIC 16 uM), C. neoformans (MIC 4 uM). Resistant strains: but Vancomycin-resistant S-aureus (MIC > 50 uM), E-coli ESBL (MIC > 5
Evidence 29 Activity

Activity

50% Cytotoxicity
Toxicity
169.6 ± 1.1 µM
Cytotoxic
50% Cytotoxicity | 169.6 ± 1.1 | µM | target cell: Vero E6 cells

Target

Vero E6 cells

Source & Reference

NA
DBAASP
Bomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses. | Front Immunol | 2022
Evidence 30 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.35663971]Vero E6 cells:CC50=169.6 ± 1.1 µM.

Source & Reference

NA
DRAMP
Front Immunol. 2022 May 19 13:851642.