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Peptide record

TPDB16245

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB16245
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, PD_Hemolysis, and other sources, with an available 3D structural model.
Sequence
FLGSLFSIGSKLLPGVIKLFQRKKQ
Physicochemical Analysis
C134H222N34O31
ANDCEHMTWY
L
2805.45
11.80
5
0
11
+5
0.06
0.332
120.80
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
2
I
5
L
4
K
0
M
3
F
1
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 2 L: 5 K: 4 M: 0 F: 3 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
25
C134H222N34O31
2805.45
11.80
+5
0.06
0.332
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli (MIC 10 uM), S. aureus (MIC 2.5-5 uM), B. subtilis (MIC 0.5-1 uM) A. baumannii (MIC 0.9 uM 2.5 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Active against E. coli (MIC 10 uM), S. aureus (MIC 2.5-5 uM), B. subtilis (MIC 0.5-1 uM) A. baumannii (MIC 0.9 uM 2.5 ug/ml). Only Im-5 showed insec
Evidence 3 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

Active against E. coli (MIC 10 uM), S. aureus (MIC 2.5-5 uM), B. subtilis (MIC 0.5-1 uM) A. baumannii (MIC 0.9 uM 2.5 ug/ml). Only Im-5 showed insecticidal activity among three
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
2.7 µM
Hemolytic Cytotoxic
10% Hemolysis | 2.7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of the scorpion venom-derived antimicrobial peptide Hp1404 as a new antimicrobial agent against carbapenem-resistant Acinetobacter baumannii. | Microb Pathog | 2021
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
28 µM
Hemolytic Cytotoxic
50% Hemolysis | 28 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Complete de novo sequencing of antimicrobial peptides in the venom of the scorpion Isometrus maculatus. | Toxicon | 2017
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis