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Peptide record

TPDB16211

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB16211
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
WDPYFAGVKKLTKAILAVRA
Physicochemical Analysis
C108H171N27O25
NCEQHMS
A
2247.71
10.46
4
1
12
+3
-0.28
0.295
107.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
6990
310.98
2
Residue Composition
number
4
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
3
K
0
M
1
F
1
P
0
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 3 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
20
C108H171N27O25
2247.71
10.46
+3
-0.28
0.295
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Escherichia coli DH5alpha-GFP strain

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli DH5alpha-GFP strain (MIC 50 uM) and S. aureus SH1000-GFP strain (MIC 50 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus SH1000-GFP strain

Source & Reference

dbAMP

Other

active against E. coli DH5alpha-GFP strain (MIC 50 uM) and S. aureus SH1000-GFP strain (MIC 50 uM).
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Rational Design of Membrane-Pore-Forming Peptides. | Small | 2017
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HDME: Not active up to 100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Small. 2017 Oct 13(40).