Back to search

Peptide record

TPDB16200

IMT-P8 (CPP2) P8 Antibacterial Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB16200
IMT-P8 (CPP2) P8
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
RRWRRWNRFNRRRCR
Physicochemical Analysis
C96H156N46O18S1
ADEQGHILKMPSTYV
R
2274.65
12.94
9
0
3
+9
3.06
-2.933
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
483.59
3
Residue Composition
number
0
A
9
R
2
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C96H156N46O18S1
2274.65
12.94
+9
3.06
-2.933
Free
L
Cationic Cationic and amphipathic
Linear Helical
Free
N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, A549,Caco-2, THP-1, and RAW264.7 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Salmonella phage selz
Late Endosomes/Lysosomes
In vitro
CCCCCCGGGGSCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

B16-F10 Cells , PC-12 Cells ,B16-F10 And Human Dermal Fibroblasts (Hdfs)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FITC at N terminal
CPP-2 displayed the highest cellular uptake at 99.8%
In vitro
CCCCCHHHHHHCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Assay & Model

P. falciparum trophozoite stage cells
P. falciparum trophozoite stage cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
SYBR green-I, doxorubicin and actinomycin D
In vivo
CCCCCCCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 And HeLa Cells , Staphylococcus Atcc 33591

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Helical L Cationic and amphipathic
Synthetic
FITC labelled
Cytoplasm
P8–antibiotics combination was more effective
In vitro
CCCCCSSCGGGTCCCC
Additional Detail Fields 1 fields
CCCCCCGGGGSCCCC CCCCCHHHHHHCC CCCCCCCCCC CCCCCSSCGGGTCCCC