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Peptide record

TPDB16167

Antibacterial standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16167
Antibacterial
Anti-infective peptides
dbAMP
standard
No
A 12-aa standard-residue antibacterial peptide sequence curated from dbAMP, with an available 3D structural model.
Sequence
RWKIFKKVVKKV
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C77H131N21O13
ANDCEQGHLMPSTY
K
1559.02
11.85
6
0
6
+6
1.69
-0.417
105.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
3.53
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
5
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
12 reviewed residue count
C77H131N21O13 sequence-only estimate (linear, free termini)
1559.02 sequence-only estimate (linear, free termini)
11.85 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.69 sequence-only estimate (linear, free termini)
-0.417 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa ATCC 25853

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
ve against E-coli ATCC 25922/KCTC 1682 (MIC >64 uM), A-baumannii ATCC 19606 (MIC >64 uM), P. aeruginosa ATCC 25853 (MIC 32 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), S-aureus ATCC 25922/KCTC 1621 (MIC >64 uM), E-fae