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Peptide record

TPDB16151

QL17 Antibacterial Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB16151
QL17
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
Sequence
QAIIHNEKVQAHGKKVL
Physicochemical Analysis
C85H145N27O23
RDCMFPSTWY
K
1913.25
10.32
5
1
7
+2
7.12
-0.453
114.71
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
2
Q
1
G
2
H
2
I
1
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 1 H: 2 I: 2 L: 1 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
17
C85H145N27O23
1913.25
10.32
+2
7.12
-0.453
Free
L
Hydrophobic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PBMC, Vero Cells, Hacat Cells, And 3T3-L1 Cells Bacterial Cell =Escherichia Coli (Atcc 25922), Klebsiella Pneumoniae (Atcc 27736), Pseudomonas Aeruginosa (Atcc 27853), Bacillus Subtilis (Atcc 6633), Staphylococcus Aureus (Atcc 25923) And Staphylococcus Epidermidis

Assay & Model

Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 27736), Pseudomonas aeruginosa (ATCC 27853), Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis
Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 27736), Pseudomonas aeruginosa (ATCC 27853), Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Hydrophobic
Protein derived
Lower membrane depth penetrating QL17 had very high MIC(>200 μg/mL for all strains).
In vitro and in vivo