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Peptide record

TPDB16147

Antibacterial Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB16147
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia
standard
No
A 19-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
FLPKLFAKITKKNMAHIRC
Physicochemical Analysis
C105H175N29O22S2
DEQGSWYV
K
2259.85
10.98
6
0
9
+5
1.93
0.058
92.63
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
1
R
1
N
0
D
1
C
0
E
0
Q
0
G
1
H
2
I
2
L
4
K
1
M
2
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 2 K: 4 M: 1 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C105H175N29O22S2
2259.85
10.98
+5
1.93
0.058
Evidence Records 3 records
Evidence 1 Activity

Activity

8.9% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
8.9% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria. | Sci Rep | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
4 %
Hemolytic
Hemolytic_activity: [Ref.30872680] 4% hemolysis at 10 µM, 9% hemolysis at 50 µM, 8% hemolysis at 100µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 9: 4485. Published online 2019 Mar 14. doi: 10.1038/s41598-019-41005-7
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
4 %
Hemolytic
Hemolytic_activity: [Ref.30872680] 4% hemolysis at 10 µM, 6% hemolysis at 50 µM, 9% hemolysis at 100µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 9: 4485. Published online 2019 Mar 14. doi: 10.1038/s41598-019-41005-7