TPDB

3D PDB MODEL

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TPDB ID TPDB16115

Peptide_Name

adD69–83 adD69–84

Activity

Antibacterial Cell-penetrating Peptides

Activity_category_statistics

Anti-infective peptides Delivery and barrier-penetrating peptides

Database_Source

dbAMP CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.

Modification

N-terminal: Biotinylation

Sequence

RRDRRRRSVCHARTWF

FASTA

>TPDB16115|Antibacterial;Cell-penetrating Peptides|length=16
RRDRRRRSVCHARTWF

Formula C90H148N40O21S1

Absent Amino Acids NEQGILKMPY

Common Amino Acids R

Mass 2158.48

PI 12.53

Basic Residues 8

Acidic Residues 1

Hydrophobic Residues 4

Net Charge +6

Boman Index 4.81

Hydrophobicity -1.831

Aliphatic Index 24.38

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 254.81

Polar Residues 3

number

1

A

7

R

0

N

1

D

1

C

0

E

0

Q

0

G

1

H

0

I

0

L

0

K

0

M

1

F

0

P

1

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 7 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1

Length

16

Formula

C90H148N40O21S1

Mass

2158.48

PI

12.53

Net Charge

+6

Boman Index

4.81

Hydrophobicity

-1.831

C_terminal_Modification

Free

Chirality

L

Ionic_State

Cationic

Linearity

Linear

N_terminal_Modification

Biotinylation

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line U87G Cells And Dermal Human Primary Fibroblasts (Dhf) S. Agalactiae Mutant Nem 316 Δdlta Strain

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Protein derived

Cargo Type Streptavidin–HRP

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCGGGTSSCSSCCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line U87G Cells And Dermal Human Primary Fibroblasts (Dhf) S. Agalactiae Mutant Nem 316 Δdlta Strain

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Protein derived

Cargo Type Streptavidin–HRP

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCGGGTSSCSSCCC

DSSP_Secondary_Structure

CCCGGGTSSCSSCCC